Open Targets MCP Server

A read-only MCP server for exploring targets, diseases, drugs and genetic evidence through the Open Targets Platform. Use names or IDs, retrieve supporting evidence, and explore drug-repurposing candidates. No Open Targets API key required.

Install

Requires uv.

Claude Code

claude mcp add opentargets -- uvx opentargets-mcp

Claude Desktop and Cursor: add this to claude_desktop_config.json (Settings → Developer → Edit Config) or ~/.cursor/mcp.json, then restart:

{
  "mcpServers": {
    "opentargets": {
      "command": "uvx",
      "args": ["opentargets-mcp"]
    }
  }
}

VS Code

code --add-mcp '{"name":"opentargets","command":"uvx","args":["opentargets-mcp"]}'

Codex

codex mcp add opentargets -- uvx opentargets-mcp

Any other stdio MCP client works the same way: command uvx, argument opentargets-mcp.

Tips:

• If the client reports spawn uvx ENOENT, use the full path from which uvx.
• Use opentargets-mcp@latest as the argument to pick up new releases.
• On Apple Silicon, a cryptography build error can indicate uv picked an Intel (Rosetta) Python. uv python find is a first clue; cached tool environments and desktop clients may use a different interpreter.

What you can ask

• “Which drugs target EGFR, and how far along are they?”
• “Which genes are most strongly associated with asthma?”
• “Show the evidence linking BRAF to melanoma.”
• “Suggest drug repurposing candidates for type 2 diabetes.”

Use names or IDs: gene symbols, disease and drug names, rsIDs, or Ensembl, MONDO and ChEMBL IDs. If a name matches several entities, the tool lists the candidates so you can pick one.

Tools

68 tools. Run uvx opentargets-mcp --list-tools for the full list.