Unofficial Open Targets MCP Server 🧬

Unofficial Model Context Protocol server for accessing Open Targets platform data for gene-drug-disease associations research.

Developed by Augmented Nature

✅ Verified Features

All 6 tools working with live Open Targets API data:

• 🎯 Target Search - Gene symbols, names, descriptions (BRCA1, TP53, etc.)
• 🦠 Disease Search - Names, synonyms, descriptions (cancer, diabetes, etc.)
• 🔗 Target-Disease Associations - Evidence scores from 20+ databases
• 📊 Disease Target Summaries - Prioritized therapeutic targets
• 🧬 Target Details - Comprehensive gene/protein information
• 🎭 Disease Details - Complete disease profiles with ontologies

🚀 Quick Start

# Install and build
npm install
npm run build

# Run the server
node build/index.js

📋 MCP Client Configuration

Claude Desktop

{
  "mcpServers": {
    "opentargets-server": {
      "command": "node",
      "args": ["/path/to/opentargets-server/build/index.js"]
    }
  }
}

Other MCP Clients

node /path/to/opentargets-server/build/index.js

🛠️ Available Tools

🎯 search_targets

Search therapeutic targets by gene symbol, name, or description

{
  "name": "search_targets",
  "arguments": {
    "query": "BRCA1", // Gene symbol, name, or description
    "size": 10 // Optional: 1-500 results (default: 25)
  }
}

Example Results:

• BRCA1 (ENSG00000012048) - BRCA1 DNA repair associated
• BRCA2 (ENSG00000139618) - BRCA2 DNA repair associated
• BRIP1 (ENSG00000136492) - BRCA1 interacting DNA helicase 1

🦠 search_diseases

Search diseases by name, synonym, or description

{
  "name": "search_diseases",
  "arguments": {
    "query": "breast cancer", // Disease name, synonym, or description
    "size": 10 // Optional: 1-500 results (default: 25)
  }
}

🔗 get_target_disease_associations

Get target-disease associations with evidence scores

{
  "name": "get_target_disease_associations",
  "arguments": {
    "targetId": "ENSG00000012048", // Target Ensembl ID
    "size": 10 // Optional: 1-500 results
  }
}

OR

{
  "name": "get_target_disease_associations",
  "arguments": {
    "diseaseId": "EFO_0000305", // Disease EFO ID
    "size": 10 // Optional: 1-500 results
  }
}

📊 get_disease_targets_summary

Get prioritized targets associated with a disease

{
  "name": "get_disease_targets_summary",
  "arguments": {
    "diseaseId": "EFO_0000305", // Disease EFO ID (required)
    "size": 20 // Optional: 1-500 targets (default: 50)
  }
}

🧬 get_target_details

Get comprehensive target information

{
  "name": "get_target_details",
  "arguments": {